Assay Detail
Functional
CHEMBL653294
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Concentration required to protect CEM/TK- cells against cytopathicity of HIV-2 by 50%
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.11 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323261 | — | — | 1 | 7.33 |
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL124801 | — | — | 1 | 6.47 |
| CHEMBL126572 | — | — | 1 | 6.40 |
| CHEMBL124586 | — | — | 1 | 6.10 |
| CHEMBL125938 | — | — | 1 | 5.92 |
| CHEMBL338306 | — | — | 1 | 5.87 |
| CHEMBL123953 | — | — | 1 | 5.30 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323261 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL124801 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL126572 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL124586 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL125938 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL338306 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL123953 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL991 | STAVUDINE | EC50 | = | 33000.0 | nM | 4.48 |