Assay Detail
Functional
CHEMBL653397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity for growth inhibition in tissue culture of human leukemias (CCRF-CEM)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.42 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.54 |
| CHEMBL174478 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL174478 | — | IC50 | = | 5000.0 | nM | 5.30 |