Assay Detail
Binding
CHEMBL653410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against bradykinin receptor B2 from guinea pig ileum.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
NMR and computational evidence that high-affinity bradykinin receptor antagonists adopt C-terminal beta-turns.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.63 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | 4.0 | 1 | 9.96 |
| CHEMBL2369941 | — | — | 1 | 9.80 |
| CHEMBL2028979 | — | — | 1 | 9.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL2369941 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL2028979 | — | Ki | = | 0.75 | nM | 9.12 |