Assay Detail
Functional
CHEMBL653412
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Antagonistic activity against Bradykinin receptor B2 of guinea pig ileum longitudinal smooth muscle.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.03 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370699 | — | — | 1 | 8.20 |
| CHEMBL384846 | — | — | 1 | 6.10 |
| CHEMBL410363 | — | — | 1 | 6.00 |
| CHEMBL337833 | — | — | 1 | 6.00 |
| CHEMBL339159 | — | — | 1 | 5.90 |
| CHEMBL1793829 | — | — | 1 | 5.70 |
| CHEMBL2370700 | — | — | 1 | 5.50 |
| CHEMBL265814 | — | — | 1 | 5.50 |
| CHEMBL264517 | — | — | 1 | 5.40 |
| CHEMBL131647 | — | — | 1 | - |
| CHEMBL405644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370699 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL384846 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL410363 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL337833 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL339159 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL1793829 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL2370700 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL265814 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL264517 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL131647 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL405644 | — | Kd | > | 10000.0 | nM | - |