Assay Detail
Binding
CHEMBL653466
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In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.52 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263746 | — | — | 1 | 8.10 |
| CHEMBL331090 | — | — | 1 | 7.55 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.52 |
| CHEMBL124416 | — | — | 1 | 7.30 |
| CHEMBL122450 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263746 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL331090 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL124416 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL122450 | — | IC50 | = | 72.0 | nM | 7.14 |