Assay Detail
Functional
CHEMBL653488
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Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cell
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.62 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.82 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.54 |
| CHEMBL302362 | — | — | 1 | 8.24 |
| CHEMBL32812 | — | — | 1 | 8.12 |
| CHEMBL342426 | — | — | 1 | 7.83 |
| CHEMBL137103 | — | — | 1 | 7.83 |
| CHEMBL138283 | — | — | 1 | 7.78 |
| CHEMBL428125 | — | — | 1 | 7.66 |
| CHEMBL134421 | — | — | 1 | 7.61 |
| CHEMBL135138 | — | — | 1 | 7.58 |
| CHEMBL435822 | — | — | 1 | 7.54 |
| CHEMBL344644 | — | — | 1 | 7.50 |
| CHEMBL137902 | — | — | 1 | 7.50 |
| CHEMBL137956 | — | — | 1 | 7.43 |
| CHEMBL342190 | — | — | 1 | 7.32 |
| CHEMBL335591 | — | — | 1 | 7.24 |
| CHEMBL344627 | — | — | 1 | 7.24 |
| CHEMBL136464 | — | — | 1 | 7.22 |
| CHEMBL344048 | — | — | 1 | 7.12 |
| CHEMBL337262 | — | — | 1 | 6.93 |
| CHEMBL136915 | — | — | 1 | 6.86 |
| CHEMBL101914 | — | — | 1 | 6.81 |
| CHEMBL139468 | — | — | 1 | - |
| CHEMBL139631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL302362 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL32812 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL342426 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL137103 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL138283 | — | EC50 | = | 16.8 | nM | 7.78 |
| CHEMBL428125 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL134421 | — | EC50 | = | 24.4 | nM | 7.61 |
| CHEMBL135138 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL435822 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL344644 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL137902 | — | EC50 | = | 31.5 | nM | 7.50 |
| CHEMBL137956 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL342190 | — | EC50 | = | 47.7 | nM | 7.32 |
| CHEMBL335591 | — | EC50 | = | 57.8 | nM | 7.24 |
| CHEMBL344627 | — | EC50 | = | 57.8 | nM | 7.24 |
| CHEMBL136464 | — | EC50 | = | 59.5 | nM | 7.22 |
| CHEMBL344048 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL337262 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL136915 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL101914 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL139468 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL139631 | — | EC50 | > | 10000.0 | nM | - |