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Assay Detail

CHEMBL653597

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
The concentration of compound to inhibit beta-lactamase was measured on Escherichia coli WC3310
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Beta-lactamase TEM (CHEMBL2065)
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

Synthesis and biological activity of 7-alkylidenecephems.
Buynak JD, Wu K, Bachmann B, Khasnis D, Hua L, Nguyen HK, Carver CL.
J Med Chem (1995) 38 : 1022 -1034
PubMed 7699694 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 6.68 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL268919 1 8.30
CHEMBL8290 CLAVULANIC ACID (SODIUM) 1 7.22
CHEMBL268632 1 6.10
CHEMBL8111 1 5.08
CHEMBL8353 1 -
CHEMBL268860 1 -
CHEMBL7995 1 -
CHEMBL8511 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL268919 IC50 = 5.0 nM 8.30
CHEMBL8290 CLAVULANIC ACID (SODIUM) IC50 = 60.0 nM 7.22
CHEMBL268632 IC50 = 800.0 nM 6.10
CHEMBL8111 IC50 = 8300.0 nM 5.08
CHEMBL8353 IC50 > 20000.0 nM -
CHEMBL268860 IC50 > 20000.0 nM -
CHEMBL7995 IC50 > 20000.0 nM -
CHEMBL8511 IC50 > 20000.0 nM -