Assay Detail
Binding
CHEMBL653603
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Inhibition constant (Ki) for TEM-1 beta-lactamase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.80 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 6.10 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 6.10 |
| CHEMBL124880 | — | — | 1 | 5.00 |
| CHEMBL891 | CLOXACILLIN | 4.0 | 1 | 4.89 |
| CHEMBL29 | PENICILLIN G | 4.0 | 1 | 4.70 |
| CHEMBL333494 | — | — | 1 | 4.70 |
| CHEMBL125999 | — | — | 1 | 4.70 |
| CHEMBL125658 | — | — | 1 | 4.41 |
| CHEMBL338512 | — | — | 1 | 4.40 |
| CHEMBL122500 | — | — | 1 | 4.30 |
| CHEMBL125652 | — | — | 1 | 4.22 |
| CHEMBL338243 | — | — | 1 | 4.08 |
| CHEMBL123270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403 | SULBACTAM | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL124880 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL891 | CLOXACILLIN | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL29 | PENICILLIN G | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL333494 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL125999 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL125658 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL338512 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL122500 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL125652 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL338243 | — | Ki | = | 83000.0 | nM | 4.08 |
| CHEMBL123270 | — | Ki | = | 160000.0 | nM | - |