Assay Detail
Functional
CHEMBL653611
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Inhibitory activity against CEM cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.32 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65013 | — | — | 1 | 6.50 |
| CHEMBL347721 | — | — | 1 | 6.47 |
| CHEMBL152959 | — | — | 1 | 6.43 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 6.41 |
| CHEMBL358876 | — | — | 1 | 6.39 |
| CHEMBL152988 | — | — | 1 | 6.25 |
| CHEMBL23843 | — | — | 1 | 6.16 |
| CHEMBL150777 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65013 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL347721 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL152959 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL358876 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL152988 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL23843 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL150777 | — | IC50 | = | 1100.0 | nM | 5.96 |