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Assay Detail

CHEMBL653614

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against radioligand [3H]SB-202190 binding to CSBP kinase in human monocytic cell line, THP-1
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL.
J Med Chem (1996) 39 : 3929 -3937
PubMed 8831759 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 6.27 7.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL10 SB-203580 — 1 7.38
CHEMBL129748 — — 1 7.16
CHEMBL339699 — — 1 7.16
CHEMBL129240 — — 1 7.10
CHEMBL126023 — — 1 7.10
CHEMBL338820 — — 1 7.10
CHEMBL96741 — — 1 7.05
CHEMBL127115 — — 1 7.00
CHEMBL14112 SB-210313 — 1 6.92
CHEMBL128889 — — 1 6.92
CHEMBL338803 — — 1 6.92
CHEMBL126259 — — 1 6.89
CHEMBL436196 — — 1 6.82
CHEMBL129297 — — 1 6.72
CHEMBL338402 — — 1 6.68
CHEMBL63135 — — 1 6.68
CHEMBL340068 — — 1 6.57
CHEMBL126690 — — 1 6.54
CHEMBL340565 — — 1 6.54
CHEMBL128638 — — 1 6.50
CHEMBL338473 — — 1 6.47
CHEMBL129063 — — 1 6.47
CHEMBL340406 — — 1 6.43
CHEMBL313417 — — 1 6.40
CHEMBL126576 — — 1 6.34
CHEMBL340014 — — 1 6.32
CHEMBL420352 — — 1 6.29
CHEMBL126915 — — 1 6.28
CHEMBL339680 — — 1 6.20
CHEMBL129497 — — 1 6.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL10 SB-203580 IC50 = 42.0 nM 7.38
CHEMBL129748 — IC50 = 70.0 nM 7.16
CHEMBL339699 — IC50 = 70.0 nM 7.16
CHEMBL129240 — IC50 = 80.0 nM 7.10
CHEMBL126023 — IC50 = 80.0 nM 7.10
CHEMBL338820 — IC50 = 80.0 nM 7.10
CHEMBL96741 — IC50 = 90.0 nM 7.05
CHEMBL127115 — IC50 = 100.0 nM 7.00
CHEMBL14112 SB-210313 IC50 = 120.0 nM 6.92
CHEMBL128889 — IC50 = 120.0 nM 6.92
CHEMBL338803 — IC50 = 120.0 nM 6.92
CHEMBL126259 — IC50 = 130.0 nM 6.89
CHEMBL436196 — IC50 = 150.0 nM 6.82
CHEMBL129297 — IC50 = 190.0 nM 6.72
CHEMBL63135 — IC50 = 210.0 nM 6.68
CHEMBL338402 — IC50 = 210.0 nM 6.68
CHEMBL340068 — IC50 = 270.0 nM 6.57
CHEMBL126690 — IC50 = 290.0 nM 6.54
CHEMBL340565 — IC50 = 290.0 nM 6.54
CHEMBL128638 — IC50 = 320.0 nM 6.50
CHEMBL338473 — IC50 = 340.0 nM 6.47
CHEMBL129063 — IC50 = 340.0 nM 6.47
CHEMBL340406 — IC50 = 370.0 nM 6.43
CHEMBL313417 — IC50 = 400.0 nM 6.40
CHEMBL126576 — IC50 = 460.0 nM 6.34
CHEMBL340014 — IC50 = 480.0 nM 6.32
CHEMBL420352 — IC50 = 510.0 nM 6.29
CHEMBL126915 — IC50 = 520.0 nM 6.28
CHEMBL339680 — IC50 = 630.0 nM 6.20
CHEMBL129497 — IC50 = 710.0 nM 6.15
CHEMBL340879 — IC50 = 750.0 nM 6.12
CHEMBL338771 — IC50 = 760.0 nM 6.12
CHEMBL130019 — IC50 = 1180.0 nM 5.93
CHEMBL129726 — IC50 = 1170.0 nM 5.93
CHEMBL126879 — IC50 = 1400.0 nM 5.85
CHEMBL128995 — IC50 = 1470.0 nM 5.83
CHEMBL126130 — IC50 = 1810.0 nM 5.74
CHEMBL125624 — IC50 = 1890.0 nM 5.72
CHEMBL340619 — IC50 = 2980.0 nM 5.53
CHEMBL318991 — IC50 = 3050.0 nM 5.52
CHEMBL129715 — IC50 = 3830.0 nM 5.42
CHEMBL340857 — IC50 = 4740.0 nM 5.32
CHEMBL341247 — IC50 = 4950.0 nM 5.30
CHEMBL126445 — IC50 = 6460.0 nM 5.19
CHEMBL127073 — IC50 = 9000.0 nM 5.05
CHEMBL106669 — IC50 = 25000.0 nM 4.60
CHEMBL129631 — IC50 = 64700.0 nM 4.19
CHEMBL338180 — IC50 = 114000.0 nM -