Assay Detail
Binding
CHEMBL653618
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Inhibition of beta-lactamase of Escherichia coli TEM-3 (class C)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.51 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355579 | — | — | 1 | 6.78 |
| CHEMBL128220 | — | — | 1 | 6.24 |
| CHEMBL607280 | — | — | 1 | - |
| CHEMBL607279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355579 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL128220 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL607280 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL607279 | — | IC50 | = | 9000000.0 | nM | - |