Assay Detail
Functional
CHEMBL653722
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Anti-HIV-1 activity tested in human lymphocytic CEM cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 6.66 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97501 | — | — | 1 | 8.22 |
| CHEMBL2114383 | — | — | 1 | 7.37 |
| CHEMBL40302 | — | — | 1 | 7.33 |
| CHEMBL329491 | — | — | 1 | 7.19 |
| CHEMBL2114386 | — | — | 1 | 7.10 |
| CHEMBL97281 | — | — | 1 | 7.10 |
| CHEMBL262299 | — | — | 1 | 7.10 |
| CHEMBL376065 | — | — | 1 | 7.06 |
| CHEMBL95192 | — | — | 1 | 7.05 |
| CHEMBL329968 | — | — | 1 | 7.05 |
| CHEMBL31131 | — | — | 1 | 7.00 |
| CHEMBL2111587 | — | — | 1 | 6.89 |
| CHEMBL319367 | — | — | 1 | 6.89 |
| CHEMBL97289 | — | — | 1 | 6.85 |
| CHEMBL330299 | — | — | 1 | 6.85 |
| CHEMBL433371 | — | — | 1 | 6.85 |
| CHEMBL95375 | — | — | 1 | 6.85 |
| CHEMBL319963 | — | — | 1 | 6.82 |
| CHEMBL95465 | — | — | 1 | 6.80 |
| CHEMBL98298 | — | — | 1 | 6.80 |
| CHEMBL97177 | — | — | 1 | 6.80 |
| CHEMBL375567 | — | — | 1 | 6.75 |
| CHEMBL223807 | — | — | 1 | 6.75 |
| CHEMBL97159 | — | — | 1 | 6.75 |
| CHEMBL97720 | — | — | 1 | 6.72 |
| CHEMBL447232 | — | — | 1 | 6.72 |
| CHEMBL320000 | — | — | 1 | 6.72 |
| CHEMBL541464 | — | — | 1 | 6.72 |
| CHEMBL328165 | — | — | 1 | 6.72 |
| CHEMBL95272 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97501 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2114383 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL40302 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL329491 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2114386 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL97281 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL262299 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL376065 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL95192 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL329968 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL31131 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2111587 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL319367 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL95375 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL433371 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL97289 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL330299 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL319963 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL95465 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL98298 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL97177 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL375567 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL97159 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL223807 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL97720 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL447232 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL320000 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL541464 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL328165 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL95272 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL375767 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL97804 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL95695 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2165109 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL330237 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3350307 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2114301 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL606885 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL319290 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL419521 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2111583 | — | EC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL317359 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2112391 | — | EC50 | = | 11700.0 | nM | 4.93 |