Assay Detail
Binding
CHEMBL653732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL1940) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lipophilic 4-isoxazolyl-1,4-dihydropyridines: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.65 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104455 | — | — | 1 | 8.39 |
| CHEMBL325811 | — | — | 1 | 8.16 |
| CHEMBL104082 | — | — | 1 | 7.74 |
| CHEMBL317651 | — | — | 1 | 7.70 |
| CHEMBL323782 | — | — | 1 | 7.64 |
| CHEMBL539426 | — | — | 1 | 7.40 |
| CHEMBL107213 | — | — | 1 | 7.14 |
| CHEMBL105893 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104455 | — | Ki | = | 4.11 | nM | 8.39 |
| CHEMBL325811 | — | Ki | = | 6.89 | nM | 8.16 |
| CHEMBL104082 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL317651 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL323782 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL539426 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL107213 | — | Ki | = | 72.9 | nM | 7.14 |
| CHEMBL105893 | — | Ki | = | 91.1 | nM | 7.04 |