Assay Detail
Functional
CHEMBL653746
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Anti-HIV activity against HIV-I RFII strain in CEM cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.59 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7187 | COSTATOLIDE | — | 1 | 4.73 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 4.64 |
| CHEMBL282382 | — | — | 1 | 4.64 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 4.33 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7187 | COSTATOLIDE | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 22960.0 | nM | 4.64 |
| CHEMBL282382 | — | IC50 | = | 22810.0 | nM | 4.64 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 47340.0 | nM | 4.33 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 301600.0 | nM | - |