Assay Detail
Functional
CHEMBL653749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against site directed 4X AZT resistant isolate HIV-1 L100I in CEM cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.68 |
| CHEMBL107200 | — | — | 1 | 6.50 |
| CHEMBL340869 | — | — | 1 | 6.43 |
| CHEMBL129835 | — | — | 1 | 6.43 |
| CHEMBL294840 | — | — | 1 | 6.31 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL107200 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL340869 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL129835 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL294840 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 870.0 | nM | 6.06 |