Assay Detail
Functional
CHEMBL653750
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Antiviral activity against site directed 4X AZT resistant isolate HIV-1 in CEM cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.35 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.10 |
| CHEMBL107200 | — | — | 1 | 7.50 |
| CHEMBL340869 | — | — | 1 | 7.16 |
| CHEMBL294840 | — | — | 1 | 7.12 |
| CHEMBL129835 | — | — | 1 | 7.12 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL107200 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL340869 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL294840 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL129835 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 82.0 | nM | 7.09 |