Assay Detail
Functional
CHEMBL653751
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Antiviral activity against site directed resistant isolate HIV-1 K101E in CEM cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.85 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.30 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.34 |
| CHEMBL129835 | — | — | 1 | 6.79 |
| CHEMBL294840 | — | — | 1 | 6.44 |
| CHEMBL107200 | — | — | 1 | 6.23 |
| CHEMBL340869 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL129835 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL294840 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL107200 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL340869 | — | IC50 | = | 957.0 | nM | 6.02 |