Assay Detail
Functional
CHEMBL653752
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Antiviral activity against site directed resistant isolate HIV-1 K103N in CEM cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.60 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL129835 | — | — | 1 | 6.57 |
| CHEMBL107200 | — | — | 1 | 6.46 |
| CHEMBL340869 | — | — | 1 | 6.34 |
| CHEMBL294840 | — | — | 1 | 6.22 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL129835 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL107200 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL340869 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL294840 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 1440.0 | nM | 5.84 |