Assay Detail
Functional
CHEMBL653779
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Inhibition of CEM T-cell proliferation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.21 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23716 | — | — | 1 | 6.26 |
| CHEMBL23843 | — | — | 1 | 6.16 |
| CHEMBL23590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23716 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL23843 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL23590 | — | IC50 | > | 10000.0 | nM | - |