Assay Detail
Functional
CHEMBL653781
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Inhibitory activity against proliferation of CEM cell line
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.98 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422508 | — | — | 3 | 6.57 |
| CHEMBL357291 | — | — | 1 | 6.43 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 6.41 |
| CHEMBL304087 | MERIMEPODIB | 2.0 | 1 | 6.31 |
| CHEMBL356236 | — | — | 1 | 6.28 |
| CHEMBL153481 | — | — | 1 | 6.22 |
| CHEMBL153794 | — | — | 1 | 6.19 |
| CHEMBL153389 | — | — | 1 | 6.17 |
| CHEMBL434894 | — | — | 1 | 6.16 |
| CHEMBL356881 | — | — | 1 | 6.15 |
| CHEMBL153773 | — | — | 1 | 6.14 |
| CHEMBL359344 | — | — | 1 | 6.11 |
| CHEMBL153118 | — | — | 1 | 6.10 |
| CHEMBL153516 | — | — | 1 | 5.96 |
| CHEMBL155617 | — | — | 1 | 5.96 |
| CHEMBL154752 | — | — | 1 | 5.96 |
| CHEMBL153429 | — | — | 1 | 5.96 |
| CHEMBL153411 | — | — | 1 | 5.96 |
| CHEMBL357949 | — | — | 1 | 5.89 |
| CHEMBL153175 | — | — | 1 | 5.85 |
| CHEMBL357309 | — | — | 1 | 5.80 |
| CHEMBL149699 | — | — | 1 | 5.77 |
| CHEMBL154867 | — | — | 1 | 5.75 |
| CHEMBL152978 | — | — | 1 | 5.66 |
| CHEMBL153702 | — | — | 1 | 5.57 |
| CHEMBL153247 | — | — | 1 | 5.51 |
| CHEMBL153771 | — | — | 1 | 5.47 |
| CHEMBL150631 | — | — | 1 | 5.39 |
| CHEMBL152931 | — | — | 1 | 5.00 |
| CHEMBL155616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422508 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL422508 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL357291 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL304087 | MERIMEPODIB | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL356236 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL422508 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL153481 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL153794 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL153389 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL434894 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL356881 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL153773 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL359344 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL153118 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL155617 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL153429 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL153516 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL154752 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL153411 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL357949 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL153175 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL357309 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL149699 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL154867 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL152978 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL153702 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL153247 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL153771 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL150631 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL152931 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL149755 | — | IC50 | 1100.0 | nM | - | |
| CHEMBL155616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153595 | — | IC50 | > | 10000.0 | nM | - |