Assay Detail
Functional
CHEMBL653798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for the cytotoxic activity against uninfected CEM cells
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The synthesis and anti-hiv activity of pyrimidine dioxolanyl nucleosides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.07 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300793 | — | — | 1 | 7.10 |
| CHEMBL505733 | — | — | 3 | 6.72 |
| CHEMBL2115444 | — | — | 1 | 4.52 |
| CHEMBL61323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300793 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL505733 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL505733 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL505733 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2115444 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL61323 | — | IC50 | > | 100000.0 | nM | - |