Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL653866

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for inhibitory concentration on HIV-I Lai wild type in CEM-SS cell line
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Expert

Target

CEM-SS (CHEMBL614548)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Dollé V, Nguyen CH, Legraverend M, Aubertin AM, Kirn A, Andreola ML, Ventura M, Tarrago-Litvak L, Bisagni E.
J Med Chem (2000) 43 : 3949 -3962
PubMed 11052800 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.70 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL338047 1 9.70
CHEMBL319139 1 9.22
CHEMBL310976 1 8.80
CHEMBL338936 1 8.52
CHEMBL129 ZIDOVUDINE 4.0 1 8.52
CHEMBL128931 1 8.22
CHEMBL83412 1 8.10
CHEMBL57733 1 7.77
CHEMBL419971 1 7.75
CHEMBL339511 1 7.52
CHEMBL128450 1 7.30
CHEMBL129144 1 7.00
CHEMBL128255 1 6.34
CHEMBL128757 1 6.14
CHEMBL339834 1 6.00
CHEMBL341111 1 5.60
CHEMBL128661 1 5.38
CHEMBL128569 1 5.34
CHEMBL131444 1 5.18
CHEMBL340689 1 5.17
CHEMBL129076 1 5.12
CHEMBL436195 1 5.00
CHEMBL129115 1 4.92
CHEMBL435411 1 4.52
CHEMBL126931 1 4.38
CHEMBL338224 1 -
CHEMBL337616 1 -
CHEMBL128800 1 -
CHEMBL127724 1 -
CHEMBL338599 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL338047 IC50 = 0.2 nM 9.70
CHEMBL319139 IC50 = 0.6 nM 9.22
CHEMBL310976 IC50 = 1.6 nM 8.80
CHEMBL338936 IC50 = 3.0 nM 8.52
CHEMBL129 ZIDOVUDINE IC50 = 3.0 nM 8.52
CHEMBL128931 IC50 = 6.0 nM 8.22
CHEMBL83412 IC50 = 8.0 nM 8.10
CHEMBL57733 IC50 = 17.0 nM 7.77
CHEMBL419971 IC50 = 18.0 nM 7.75
CHEMBL339511 IC50 = 30.0 nM 7.52
CHEMBL128450 IC50 = 50.0 nM 7.30
CHEMBL129144 IC50 = 100.0 nM 7.00
CHEMBL128255 IC50 = 460.0 nM 6.34
CHEMBL128757 IC50 = 730.0 nM 6.14
CHEMBL339834 IC50 = 1000.0 nM 6.00
CHEMBL341111 IC50 = 2500.0 nM 5.60
CHEMBL128661 IC50 = 4200.0 nM 5.38
CHEMBL128569 IC50 = 4600.0 nM 5.34
CHEMBL131444 IC50 = 6600.0 nM 5.18
CHEMBL340689 IC50 = 6700.0 nM 5.17
CHEMBL129076 IC50 = 7500.0 nM 5.12
CHEMBL436195 IC50 = 10000.0 nM 5.00
CHEMBL129115 IC50 = 12000.0 nM 4.92
CHEMBL435411 IC50 = 30000.0 nM 4.52
CHEMBL126931 IC50 = 41400.0 nM 4.38
CHEMBL338224 IC50 > 10000.0 nM -
CHEMBL337616 IC50 > 10000.0 nM -
CHEMBL128800 IC50 > 1000.0 nM -
CHEMBL127724 IC50 > 100000.0 nM -
CHEMBL338599 IC50 > 1000.0 nM -
CHEMBL434058 IC50 > 100000.0 nM -
CHEMBL128812 IC50 > 1000.0 nM -
CHEMBL129507 IC50 > 10000.0 nM -