Assay Detail
Functional
CHEMBL653872
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The compound was tested for inhibition of nevirapine HIV-1 resistant strain
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416107 | — | — | 1 | 6.58 |
| CHEMBL336237 | — | — | 1 | 5.68 |
| CHEMBL357409 | — | — | 1 | 5.66 |
| CHEMBL128450 | — | — | 1 | 5.37 |
| CHEMBL343067 | — | — | 1 | 5.18 |
| CHEMBL359240 | — | — | 1 | 5.17 |
| CHEMBL343576 | — | — | 1 | 5.17 |
| CHEMBL140048 | — | — | 1 | 4.38 |
| CHEMBL140532 | — | — | 1 | - |
| CHEMBL341880 | — | — | 1 | - |
| CHEMBL143635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416107 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL336237 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL357409 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL128450 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL343067 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL359240 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL343576 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL140048 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL140532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341880 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL143635 | — | IC50 | > | 100000.0 | nM | - |