Assay Detail
Functional
CHEMBL653893
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Cytotoxicity against CEM T-lymphocytes.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.71 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158037 | — | — | 1 | 6.58 |
| CHEMBL152675 | — | — | 1 | 6.31 |
| CHEMBL350032 | — | — | 1 | 6.10 |
| CHEMBL152674 | — | — | 1 | 5.97 |
| CHEMBL156016 | — | — | 1 | 5.83 |
| CHEMBL154716 | — | — | 1 | 5.77 |
| CHEMBL358894 | — | — | 1 | 5.69 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.61 |
| CHEMBL155539 | — | — | 1 | 5.57 |
| CHEMBL348877 | — | — | 1 | 5.35 |
| CHEMBL347880 | — | — | 1 | 5.06 |
| CHEMBL154880 | — | — | 1 | 4.68 |
| CHEMBL151678 | — | — | 1 | - |
| CHEMBL152243 | — | — | 1 | - |
| CHEMBL151677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158037 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL152675 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL350032 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL152674 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL156016 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL154716 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL358894 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL155539 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL348877 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL347880 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL154880 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL151678 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL152243 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL151677 | — | IC50 | = | 162000.0 | nM | - |