Assay Detail
Functional
CHEMBL653911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against ovarian carcinoma cell line CH1.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CH1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.21 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 7.54 |
| CHEMBL279754 | DSB-120 | — | 1 | 7.48 |
| CHEMBL128234 | — | — | 1 | 7.23 |
| CHEMBL293096 | — | — | 1 | 7.00 |
| CHEMBL128345 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11359 | CISPLATIN | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL279754 | DSB-120 | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL128234 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL293096 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL128345 | — | IC50 | = | 160.0 | nM | 6.80 |