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Assay Detail

CHEMBL653983

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Functional
Cytotoxicity in CHO cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Intermediate

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters.
Wang C, Delcros JG, Cannon L, Konate F, Carias H, Biggerstaff J, Gardner RA, Phanstiel IV O.
J Med Chem (2003) 46 : 5129 -5138
PubMed 14613316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.89 5.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3216621 1 5.31
CHEMBL558390 1 5.12
CHEMBL543610 1 5.02
CHEMBL544167 1 5.02
CHEMBL555288 1 4.95
CHEMBL542751 1 4.81
CHEMBL3216180 1 4.80
CHEMBL558813 1 4.76
CHEMBL540552 1 4.18
CHEMBL540336 1 -
CHEMBL542262 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3216621 IC50 = 4900.0 nM 5.31
CHEMBL558390 IC50 = 7600.0 nM 5.12
CHEMBL543610 IC50 = 9500.0 nM 5.02
CHEMBL544167 IC50 = 9500.0 nM 5.02
CHEMBL555288 IC50 = 11200.0 nM 4.95
CHEMBL542751 IC50 = 15500.0 nM 4.81
CHEMBL3216180 IC50 = 15900.0 nM 4.80
CHEMBL558813 IC50 = 17400.0 nM 4.76
CHEMBL540552 IC50 = 66700.0 nM 4.18
CHEMBL540336 IC50 > 100000.0 nM -
CHEMBL542262 IC50 > 1000000.0 nM -