Assay Detail
Functional
CHEMBL654035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against human C-C chemokine receptor type 5.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Orally bioavailable competitive CCR5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.02 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59511 | — | — | 1 | 9.22 |
| CHEMBL58897 | — | — | 1 | 9.10 |
| CHEMBL61424 | — | — | 1 | 9.00 |
| CHEMBL301454 | — | — | 1 | 8.85 |
| CHEMBL61536 | — | — | 1 | 8.70 |
| CHEMBL292625 | — | — | 1 | 8.66 |
| CHEMBL58387 | — | — | 1 | 8.64 |
| CHEMBL60225 | — | — | 1 | 8.64 |
| CHEMBL58441 | — | — | 1 | 8.62 |
| CHEMBL61466 | — | — | 1 | 8.62 |
| CHEMBL62152 | — | — | 1 | 8.59 |
| CHEMBL61373 | — | — | 1 | 8.55 |
| CHEMBL58004 | — | — | 1 | 8.54 |
| CHEMBL61828 | — | — | 1 | 8.52 |
| CHEMBL556314 | — | — | 1 | 8.48 |
| CHEMBL59328 | — | — | 1 | 8.43 |
| CHEMBL58248 | — | — | 1 | 8.42 |
| CHEMBL59101 | — | — | 1 | 8.11 |
| CHEMBL59602 | — | — | 1 | 8.09 |
| CHEMBL61374 | — | — | 1 | 8.07 |
| CHEMBL58109 | — | — | 1 | 8.05 |
| CHEMBL293900 | — | — | 1 | 8.00 |
| CHEMBL58101 | — | — | 1 | 7.96 |
| CHEMBL60589 | — | — | 1 | 7.39 |
| CHEMBL58176 | — | — | 1 | 7.38 |
| CHEMBL60711 | — | — | 1 | 7.32 |
| CHEMBL416512 | — | — | 1 | 7.12 |
| CHEMBL418120 | — | — | 1 | 7.10 |
| CHEMBL60279 | — | — | 1 | 7.04 |
| CHEMBL61465 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59511 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL58897 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL61424 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL301454 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL61536 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL292625 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL58387 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL60225 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL58441 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL61466 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL62152 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL61373 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL58004 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL61828 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL556314 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL59328 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL58248 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL59101 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL59602 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL61374 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL58109 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL293900 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL58101 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL60589 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL58176 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL60711 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL416512 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL418120 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL60279 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL61465 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL294271 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL292894 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL433635 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL59285 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL304931 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL59358 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL59492 | — | IC50 | > | 1000.0 | nM | - |