Assay Detail
Functional
CHEMBL654087
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Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.23 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.10 |
| CHEMBL267940 | — | — | 1 | 7.77 |
| CHEMBL440454 | — | — | 1 | 7.50 |
| CHEMBL266282 | AL-43 | — | 1 | 7.48 |
| CHEMBL267231 | — | — | 1 | 7.46 |
| CHEMBL268239 | — | — | 1 | 7.21 |
| CHEMBL8394 | — | — | 1 | 6.91 |
| CHEMBL7671 | — | — | 1 | 6.89 |
| CHEMBL8209 | — | — | 1 | 6.71 |
| CHEMBL266709 | — | — | 1 | 6.26 |
| CHEMBL8639 | — | — | 1 | - |
| CHEMBL8360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL267940 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL440454 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL266282 | AL-43 | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL267231 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL268239 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL8394 | — | EC50 | = | 123.0 | nM | 6.91 |
| CHEMBL7671 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL8209 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL266709 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL8639 | — | EC50 | > | 300.0 | nM | - |
| CHEMBL8360 | — | EC50 | > | 300.0 | nM | - |