Assay Detail
Functional
CHEMBL654153
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Ability to repolarize beta-TC3 cell membrane potential
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Beta-TC3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50179 | — | — | 1 | 6.10 |
| CHEMBL111335 | — | — | 1 | 5.33 |
| CHEMBL48923 | — | — | 1 | 5.33 |
| CHEMBL420858 | — | — | 1 | 5.26 |
| CHEMBL324456 | — | — | 1 | 4.92 |
| CHEMBL109180 | — | — | 1 | 4.92 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.86 |
| CHEMBL107548 | — | — | 1 | 4.75 |
| CHEMBL301508 | — | — | 1 | 4.72 |
| CHEMBL431255 | — | — | 1 | 4.70 |
| CHEMBL298121 | — | — | 1 | 4.62 |
| CHEMBL110551 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50179 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111335 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL48923 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL420858 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL324456 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL109180 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL107548 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL301508 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL431255 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL298121 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL110551 | — | IC50 | = | 25000.0 | nM | 4.60 |