Compound Detail
CHEMBL431255
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Basic Information
| ChEMBL ID | CHEMBL431255 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BJVCFGVYAVBPJR-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
460.8
MW (Da)
6.30
ALogP
2
HBA
2
HBD
60.2
PSA (Ų)
0.19
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-TC6 CHEMBL614357 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Beta-TC3 CHEMBL614063 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.55 | 4.55 | 27900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-TC6 | IC50 | = | 2800.0 | nM | 5.55 | In vitro ability to inhibit glucose stimulated insulin release in beta-TC6 cells... | 15163199 |
| Beta-TC3 | IC50 | = | 20000.0 | nM | 4.7 | Ability to repolarize beta-TC3 cell membrane potential | 15163199 |
| Rattus norvegicus | IC50 | = | 27900.0 | nM | 4.55 | Relaxation of phenylephrine precontracted rat isolated aorta rings. | 15163199 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163199 | 10.1021/jm031018y | Beta-TC6 | 2 |
| 15163199 | 10.1021/jm031018y | Rattus norvegicus | 1 |
| 15163199 | 10.1021/jm031018y | Beta-TC3 | 1 |
Data from ChEMBL 36 via Core Engine