Assay Detail
Functional
CHEMBL650716
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In vitro ability to inhibit glucose stimulated insulin release in beta-TC6 cells from rat islets
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Beta-TC6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.05 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88083 | — | — | 1 | 5.92 |
| CHEMBL48923 | — | — | 1 | 5.70 |
| CHEMBL431255 | — | — | 1 | 5.55 |
| CHEMBL50179 | — | — | 1 | 5.38 |
| CHEMBL107548 | — | — | 1 | 5.36 |
| CHEMBL301508 | — | — | 1 | 5.30 |
| CHEMBL420858 | — | — | 1 | 5.28 |
| CHEMBL111335 | — | — | 1 | 5.26 |
| CHEMBL109180 | — | — | 1 | 4.86 |
| CHEMBL110501 | — | — | 1 | 4.79 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.65 |
| CHEMBL324456 | — | — | 1 | 4.54 |
| CHEMBL110551 | — | — | 1 | 4.40 |
| CHEMBL109198 | — | — | 1 | 4.38 |
| CHEMBL298121 | — | — | 1 | 4.31 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88083 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL48923 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL431255 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL50179 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL107548 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL301508 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL420858 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL111335 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL109180 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL110501 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL324456 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL110551 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL109198 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL298121 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | > | 100000.0 | nM | - |