Compound Detail
CHEMBL88083
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Basic Information
| ChEMBL ID | CHEMBL88083 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBLLTWXDTMLVSQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
231.3
MW (Da)
1.97
ALogP
3
HBA
2
HBD
73.1
PSA (Ų)
0.36
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-TC6 CHEMBL614357 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-TC6 | IC50 | = | 1200.0 | nM | 5.92 | In vitro ability to inhibit glucose stimulated insulin release in beta-TC6 cells... | 15163199 |
| Rattus norvegicus | IC50 | = | 11000.0 | nM | 4.96 | Relaxation of phenylephrine precontracted rat isolated aorta rings. | 15163199 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163199 | 10.1021/jm031018y | Beta-TC6 | 2 |
| 15163199 | 10.1021/jm031018y | Rattus norvegicus | 1 |
| 15163199 | 10.1021/jm031018y | Beta-TC3 | 1 |
| 7359512 | 10.1021/jm00175a005 | Rattus norvegicus | 1 |
| 691003 | 10.1021/jm00206a011 | Mus musculus | 1 |
| 691003 | 10.1021/jm00206a011 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine