Assay Detail
Functional
CHEMBL796592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxation of phenylephrine precontracted rat isolated aorta rings.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.84 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298121 | — | — | 1 | 6.52 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.10 |
| CHEMBL295342 | — | — | 1 | 6.05 |
| CHEMBL48923 | — | — | 1 | 5.25 |
| CHEMBL88083 | — | — | 1 | 4.96 |
| CHEMBL109180 | — | — | 1 | 4.92 |
| CHEMBL301508 | — | — | 1 | 4.91 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.89 |
| CHEMBL420858 | — | — | 1 | 4.75 |
| CHEMBL50179 | — | — | 1 | 4.73 |
| CHEMBL107548 | — | — | 1 | 4.69 |
| CHEMBL431255 | — | — | 1 | 4.55 |
| CHEMBL110551 | — | — | 1 | 4.52 |
| CHEMBL110501 | — | — | 1 | 4.36 |
| CHEMBL111332 | — | — | 1 | 4.28 |
| CHEMBL109198 | — | — | 1 | 4.21 |
| CHEMBL324456 | — | — | 1 | 4.12 |
| CHEMBL111048 | — | — | 1 | 4.12 |
| CHEMBL107725 | — | — | 1 | 4.07 |
| CHEMBL111335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298121 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL295342 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL48923 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL88083 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL109180 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL301508 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL420858 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL50179 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL107548 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL431255 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL110551 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL110501 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL111332 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL109198 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL324456 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL111048 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL107725 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL111335 | — | IC50 | > | 300000.0 | nM | - |