Assay Detail
Binding
CHEMBL654243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against [3H]flunitrazepam binding to Benzodiazepine receptor in bovine brain membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Pyrazolo[4,5-c]quinolines. 2. Synthesis and specific inhibition of benzodiazepine receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.53 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330083 | — | — | 1 | 6.58 |
| CHEMBL91040 | — | — | 1 | 6.00 |
| CHEMBL313315 | — | — | 1 | 5.57 |
| CHEMBL101206 | — | — | 1 | 5.47 |
| CHEMBL101154 | — | — | 1 | 5.36 |
| CHEMBL317317 | — | — | 1 | 5.05 |
| CHEMBL419527 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330083 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL91040 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL313315 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL101206 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL101154 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL317317 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL419527 | — | IC50 | = | 22000.0 | nM | 4.66 |