Assay Detail
Binding
CHEMBL654268
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Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular muscle in the presence of 1 uM zinterol
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.37 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162513 | — | — | 1 | 6.80 |
| CHEMBL349978 | — | — | 1 | 6.64 |
| CHEMBL350847 | — | — | 1 | 6.27 |
| CHEMBL165901 | — | — | 1 | 6.17 |
| CHEMBL162200 | — | — | 1 | 5.96 |
| CHEMBL350432 | — | — | 1 | 5.96 |
| CHEMBL163587 | — | — | 1 | 5.77 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 5.70 |
| CHEMBL9666 | — | — | 1 | 5.70 |
| CHEMBL162182 | — | — | 1 | 5.64 |
| CHEMBL163153 | — | — | 1 | 5.52 |
| CHEMBL350581 | — | — | 1 | 5.48 |
| CHEMBL59597 | — | — | 1 | 5.10 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.05 |
| CHEMBL9841 | — | — | 1 | 4.92 |
| CHEMBL165175 | — | — | 1 | 4.92 |
| CHEMBL165012 | — | — | 1 | 4.89 |
| CHEMBL9746 | — | — | 1 | 4.85 |
| CHEMBL114478 | — | — | 1 | 4.82 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 4.72 |
| CHEMBL351183 | — | — | 1 | 4.58 |
| CHEMBL162095 | — | — | 1 | 4.51 |
| CHEMBL165462 | — | — | 1 | 4.42 |
| CHEMBL59517 | — | — | 1 | 4.42 |
| CHEMBL163363 | — | — | 1 | - |
| CHEMBL166330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162513 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL349978 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL350847 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL165901 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL162200 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL350432 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL163587 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL9666 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL162182 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL163153 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL350581 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL59597 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL471 | SOTALOL | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL9841 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL165175 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL165012 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL9746 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL114478 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL9434 | PHENYLPIPERAZINE | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL351183 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL162095 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL165462 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL59517 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL163363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL166330 | — | IC50 | > | 100000.0 | nM | - |