Assay Detail
Functional
CHEMBL654290
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Inhibitory activity (IC50) against human glucocorticoid receptor expressed in CV-1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 8.00 |
| CHEMBL32812 | — | — | 1 | 6.34 |
| CHEMBL134421 | — | — | 1 | 6.13 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL32812 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL134421 | — | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL103 | PROGESTERONE | IC50 | > | 1000.0 | nM | - |