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Assay Detail

CHEMBL654295

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against growth of monkey normal kidney epithelial cells as a measure of compound toxicity
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cercopithecidae
Cell Type CV-1
Confidence 1 — Organism
Curated By Expert

Target

CV-1 (CHEMBL613507)
Type CELL-LINE
Organism Chlorocebus aethiops

Publication

Synthesis and evaluation of novel rhodacyanine dyes that exhibit antitumor activity.
Kawakami M, Koya K, Ukai T, Tatsuta N, Ikegawa A, Ogawa K, Shishido T, Chen LB.
J Med Chem (1997) 40 : 3151 -3160
PubMed 9379434 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.32 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL106428 1 7.00
CHEMBL319655 1 6.10
CHEMBL81782 1 5.92
CHEMBL319847 1 5.82
CHEMBL418810 1 5.77
CHEMBL106653 1 5.66
CHEMBL108063 1 5.52
CHEMBL325978 1 5.47
CHEMBL321480 1 5.47
CHEMBL286127 1 5.19
CHEMBL444282 1 5.01
CHEMBL110084 1 4.79
CHEMBL108793 1 4.76
CHEMBL110194 1 4.59
CHEMBL321025 1 4.58
CHEMBL322227 1 4.41
CHEMBL325127 1 4.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL106428 IC50 = 100.0 nM 7.00
CHEMBL319655 IC50 = 800.0 nM 6.10
CHEMBL81782 IC50 = 1200.0 nM 5.92
CHEMBL319847 IC50 = 1500.0 nM 5.82
CHEMBL418810 IC50 = 1700.0 nM 5.77
CHEMBL106653 IC50 = 2200.0 nM 5.66
CHEMBL108063 IC50 = 3000.0 nM 5.52
CHEMBL325978 IC50 = 3400.0 nM 5.47
CHEMBL321480 IC50 = 3400.0 nM 5.47
CHEMBL286127 IC50 = 6500.0 nM 5.19
CHEMBL444282 IC50 = 9800.0 nM 5.01
CHEMBL110084 IC50 = 16200.0 nM 4.79
CHEMBL108793 IC50 = 17300.0 nM 4.76
CHEMBL110194 IC50 = 25400.0 nM 4.59
CHEMBL321025 IC50 = 26200.0 nM 4.58
CHEMBL322227 IC50 = 38900.0 nM 4.41
CHEMBL325127 IC50 = 46100.0 nM 4.34