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Assay Detail

CHEMBL654296

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration in CV-1 cell
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cercopithecidae
Cell Type CV-1
Confidence 1 — Organism
Curated By Expert

Target

CV-1 (CHEMBL613507)
Type CELL-LINE
Organism Chlorocebus aethiops

Publication

5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Tegley CM, Zhi L, Marschke KB, Gottardis MM, Yang Q, Jones TK.
J Med Chem (1998) 41 : 4354 -4359
PubMed 9784110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.65 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428125 1 8.49
CHEMBL344644 1 6.66
CHEMBL138283 1 6.57
CHEMBL101914 1 6.54
CHEMBL139631 1 6.37
CHEMBL135138 1 6.28
CHEMBL139468 1 6.23
CHEMBL136915 1 6.06
CHEMBL137956 1 -
CHEMBL344627 1 -
CHEMBL137103 1 -
CHEMBL134421 1 -
CHEMBL335591 1 -
CHEMBL337262 1 -
CHEMBL342190 1 -
CHEMBL342426 1 -
CHEMBL32812 1 -
CHEMBL302362 1 -
CHEMBL136464 1 -
CHEMBL435822 1 -
CHEMBL137902 1 -
CHEMBL344048 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428125 IC50 = 3.2 nM 8.49
CHEMBL344644 IC50 = 220.0 nM 6.66
CHEMBL138283 IC50 = 270.0 nM 6.57
CHEMBL101914 IC50 = 290.0 nM 6.54
CHEMBL139631 IC50 = 425.0 nM 6.37
CHEMBL135138 IC50 = 531.0 nM 6.28
CHEMBL139468 IC50 = 590.0 nM 6.23
CHEMBL136915 IC50 = 880.0 nM 6.06
CHEMBL137956 IC50 > 10000.0 nM -
CHEMBL344627 IC50 > 10000.0 nM -
CHEMBL137103 IC50 > 10000.0 nM -
CHEMBL134421 IC50 > 10000.0 nM -
CHEMBL335591 IC50 > 10000.0 nM -
CHEMBL337262 IC50 > 10000.0 nM -
CHEMBL342190 IC50 > 10000.0 nM -
CHEMBL342426 IC50 > 10000.0 nM -
CHEMBL32812 IC50 > 10000.0 nM -
CHEMBL302362 IC50 > 10000.0 nM -
CHEMBL136464 IC50 > 10000.0 nM -
CHEMBL435822 IC50 > 10000.0 nM -
CHEMBL137902 IC50 > 10000.0 nM -
CHEMBL344048 IC50 > 10000.0 nM -