Assay Detail
Binding
CHEMBL654391
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In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.23 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137039 | — | — | 1 | 5.80 |
| CHEMBL335133 | — | — | 1 | 5.67 |
| CHEMBL146254 | — | — | 1 | 5.59 |
| CHEMBL343780 | — | — | 1 | 5.51 |
| CHEMBL359415 | — | — | 1 | 5.49 |
| CHEMBL344593 | — | — | 1 | 5.47 |
| CHEMBL409854 | SALIGCINNAMIDE | — | 1 | 5.18 |
| CHEMBL422098 | — | — | 1 | 5.12 |
| CHEMBL147346 | — | — | 1 | 5.07 |
| CHEMBL424100 | — | — | 1 | 5.04 |
| CHEMBL343365 | — | — | 1 | 4.79 |
| CHEMBL413039 | — | — | 1 | 4.69 |
| CHEMBL343054 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137039 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL335133 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL146254 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL343780 | — | Ki | = | 3080.0 | nM | 5.51 |
| CHEMBL359415 | — | Ki | = | 3250.0 | nM | 5.49 |
| CHEMBL344593 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL409854 | SALIGCINNAMIDE | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL422098 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL147346 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL424100 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL343365 | — | Ki | = | 16200.0 | nM | 4.79 |
| CHEMBL413039 | — | Ki | = | 20300.0 | nM | 4.69 |
| CHEMBL343054 | — | Ki | = | 26300.0 | nM | 4.58 |