Assay Detail
Binding
CHEMBL654400
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Concentration that causes 50% inhibition of Butyrylcholinesterase (BChE) using human serum and BW284c51
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Serum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Homodimeric tacrine congeners as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.23 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307908 | — | — | 1 | 8.59 |
| CHEMBL308962 | — | — | 1 | 8.48 |
| CHEMBL306492 | — | — | 1 | 8.42 |
| CHEMBL75985 | — | — | 1 | 7.64 |
| CHEMBL307004 | — | — | 1 | 7.58 |
| CHEMBL74940 | — | — | 1 | 7.35 |
| CHEMBL75274 | — | — | 1 | 7.28 |
| CHEMBL32823 | — | — | 1 | 7.27 |
| CHEMBL76173 | — | — | 1 | 7.23 |
| CHEMBL73800 | — | — | 1 | 7.08 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.05 |
| CHEMBL75305 | — | — | 1 | 7.03 |
| CHEMBL312761 | — | — | 1 | 6.79 |
| CHEMBL74827 | — | — | 1 | 6.78 |
| CHEMBL312310 | — | — | 1 | 6.71 |
| CHEMBL74927 | — | — | 1 | 6.59 |
| CHEMBL421501 | — | — | 1 | 6.56 |
| CHEMBL73160 | — | — | 1 | 6.51 |
| CHEMBL76014 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307908 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL308962 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL306492 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL75985 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL307004 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL74940 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL75274 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL32823 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL76173 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL73800 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL95 | TACRINE | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL75305 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL312761 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL74827 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL312310 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL74927 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL421501 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL73160 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL76014 | — | IC50 | = | 328.0 | nM | 6.48 |