Assay Detail
Binding
CHEMBL654402
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Ex vivo inhibition of human plasma Butyrylcholinesterase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 8.30 |
| CHEMBL123248 | ESERIDINE | 2.0 | 1 | 7.92 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | -1.0 | 1 | 7.80 |
| CHEMBL333580 | — | — | 1 | 7.60 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.43 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.33 |
| CHEMBL332760 | — | — | 1 | 7.30 |
| CHEMBL121810 | GANSTIGMINE | 2.0 | 1 | 6.51 |
| CHEMBL538852 | — | — | 1 | 6.18 |
| CHEMBL123831 | — | — | 1 | 6.09 |
| CHEMBL123249 | — | — | 1 | 5.81 |
| CHEMBL124054 | — | — | 1 | 5.80 |
| CHEMBL538109 | — | — | 1 | 5.77 |
| CHEMBL120279 | — | — | 1 | 5.71 |
| CHEMBL122834 | — | — | 1 | 5.54 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.38 |
| CHEMBL557400 | — | — | 1 | 5.28 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.14 |
| CHEMBL556186 | — | — | 1 | - |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
| CHEMBL538853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL123248 | ESERIDINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL333580 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL95 | TACRINE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL332760 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL121810 | GANSTIGMINE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL538852 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL123831 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL123249 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL124054 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL538109 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL120279 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL122834 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL557400 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL556186 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL395280 | HUPERZINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL538853 | — | IC50 | > | 10000.0 | nM | - |