Assay Detail
Binding
CHEMBL654403
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In vitro inhibition of Butyrylcholinesterase from human erythrocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.75 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.22 |
| CHEMBL95020 | — | — | 1 | 5.66 |
| CHEMBL328468 | — | — | 1 | 5.41 |
| CHEMBL329231 | — | — | 1 | 5.40 |
| CHEMBL94546 | — | — | 1 | 5.35 |
| CHEMBL329012 | ICOPEZIL MALEATE | 2.0 | 1 | 5.14 |
| CHEMBL94217 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL95020 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL328468 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL329231 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL94546 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL329012 | ICOPEZIL MALEATE | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL94217 | — | IC50 | = | 9000.0 | nM | 5.05 |