Assay Detail
Binding
CHEMBL654405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Serum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.90 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 9.05 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.75 |
| CHEMBL75644 | — | — | 1 | - |
| CHEMBL75699 | — | — | 1 | - |
| CHEMBL310961 | — | — | 1 | - |
| CHEMBL80382 | — | — | 1 | - |
| CHEMBL80224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL75644 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL75699 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL310961 | — | IC50 | = | 960000.0 | nM | - |
| CHEMBL80382 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL80224 | — | IC50 | = | 790000.0 | nM | - |