Assay Detail
Binding
CHEMBL654407
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Inhibitory activity towards human butyrylcholinesterase
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.45 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165109 | — | — | 1 | 6.62 |
| CHEMBL95375 | — | — | 1 | 6.60 |
| CHEMBL319367 | — | — | 1 | 6.46 |
| CHEMBL95695 | — | — | 1 | 6.39 |
| CHEMBL95192 | — | — | 1 | 6.24 |
| CHEMBL375767 | — | — | 1 | 6.11 |
| CHEMBL40302 | — | — | 1 | 6.04 |
| CHEMBL317359 | — | — | 1 | 6.00 |
| CHEMBL2112391 | — | — | 1 | 5.96 |
| CHEMBL376065 | — | — | 1 | 5.92 |
| CHEMBL329491 | — | — | 1 | 5.92 |
| CHEMBL606885 | — | — | 1 | 5.89 |
| CHEMBL541464 | — | — | 1 | 5.75 |
| CHEMBL3350307 | — | — | 1 | 5.75 |
| CHEMBL97281 | — | — | 1 | 5.70 |
| CHEMBL330237 | — | — | 1 | 5.60 |
| CHEMBL2114301 | — | — | 1 | 5.58 |
| CHEMBL95465 | — | — | 1 | 5.57 |
| CHEMBL319963 | — | — | 1 | 5.55 |
| CHEMBL419521 | — | — | 1 | 5.48 |
| CHEMBL318643 | — | — | 1 | 5.47 |
| CHEMBL2114303 | — | — | 1 | 5.43 |
| CHEMBL447232 | — | — | 1 | 5.41 |
| CHEMBL329968 | — | — | 1 | 5.41 |
| CHEMBL375567 | — | — | 1 | 5.38 |
| CHEMBL97159 | — | — | 1 | 5.36 |
| CHEMBL97804 | — | — | 1 | 5.36 |
| CHEMBL223807 | — | — | 1 | 5.34 |
| CHEMBL2111583 | — | — | 1 | 5.30 |
| CHEMBL330299 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165109 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL95375 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL319367 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL95695 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL95192 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL375767 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL40302 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL317359 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2112391 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL376065 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL329491 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL606885 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL541464 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3350307 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL97281 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL330237 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2114301 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL95465 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL319963 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL419521 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL318643 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2114303 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL447232 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL329968 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL375567 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL97159 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL97804 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL223807 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2111583 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL330299 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL95272 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL328165 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL262299 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2114298 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL98298 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL320000 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL97145 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3142709 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL97501 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL31131 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL97177 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL95532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3142710 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL433371 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2114383 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2111586 | — | IC50 | > | - | nM | - |
| CHEMBL94571 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3142699 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL319290 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL316665 | — | IC50 | > | 50000.0 | nM | - |