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Assay Detail

CHEMBL654415

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Leader H, Smejkal RM, Payne CS, Padilla FN, Doctor BP, Gordon RK, Chiang PK.
J Med Chem (1989) 32 : 1522 -1528
PubMed 2738887 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.85 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36583 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36583 Ki = 1400.0 nM 5.85