Assay Detail
Binding
CHEMBL654416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.62 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288482 | — | — | 1 | 6.10 |
| CHEMBL416974 | — | — | 1 | 5.89 |
| CHEMBL1115 | PYRIDOSTIGMINE | 4.0 | 1 | 5.46 |
| CHEMBL290912 | — | — | 1 | 5.34 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288482 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL416974 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1115 | PYRIDOSTIGMINE | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL290912 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL94 | PHYSOSTIGMINE | Ki | = | 5000.0 | nM | 5.30 |