Assay Detail
Binding
CHEMBL654452
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Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.91 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 2 | 6.55 |
| CHEMBL288096 | — | — | 1 | 6.22 |
| CHEMBL27559 | — | — | 1 | 6.16 |
| CHEMBL35556 | — | — | 1 | 6.14 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.07 |
| CHEMBL285414 | — | — | 1 | 6.05 |
| CHEMBL19130 | — | — | 1 | 5.36 |
| CHEMBL284368 | — | — | 1 | 5.33 |
| CHEMBL284248 | — | — | 1 | 5.04 |
| CHEMBL36061 | — | — | 1 | - |
| CHEMBL32392 | — | — | 1 | - |
| CHEMBL32330 | — | — | 1 | - |
| CHEMBL440846 | — | — | 1 | - |
| CHEMBL286929 | — | — | 1 | - |
| CHEMBL283871 | — | — | 1 | - |
| CHEMBL286787 | — | — | 1 | - |
| CHEMBL154709 | APOCIDEINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL288096 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL27559 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL35556 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL285414 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL19130 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL284368 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL284248 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL36061 | — | IC50 | >= | 5000.0 | nM | - |
| CHEMBL32392 | — | IC50 | >= | 5000.0 | nM | - |
| CHEMBL32330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL440846 | — | IC50 | >= | 5000.0 | nM | - |
| CHEMBL286929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL283871 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL286787 | — | IC50 | >= | 5000.0 | nM | - |
| CHEMBL154709 | APOCIDEINE | IC50 | > | 10000.0 | nM | - |