Assay Detail
Binding
CHEMBL654539
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Displacement of [125I]-salmon calcitonin (sCT) from calcitonin receptor of rat brain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.03 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369912 | — | — | 1 | 9.74 |
| CHEMBL2369886 | — | — | 1 | 9.60 |
| CHEMBL2369895 | — | — | 1 | 9.49 |
| CHEMBL2369907 | — | — | 1 | 9.42 |
| CHEMBL2369915 | — | — | 1 | 9.39 |
| CHEMBL2369893 | — | — | 1 | 8.27 |
| CHEMBL2369899 | — | — | 1 | 7.22 |
| CHEMBL2369897 | — | — | 1 | 7.10 |
| CHEMBL2369906 | — | — | 1 | 6.76 |
| CHEMBL2304022 | — | — | 1 | 5.72 |
| CHEMBL2369892 | — | — | 1 | 5.61 |
| CHEMBL2369905 | — | — | 1 | - |
| CHEMBL2369898 | — | — | 1 | - |
| CHEMBL2369904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369912 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL2369886 | — | IC50 | = | 0.249 | nM | 9.60 |
| CHEMBL2369895 | — | IC50 | = | 0.326 | nM | 9.49 |
| CHEMBL2369907 | — | IC50 | = | 0.377 | nM | 9.42 |
| CHEMBL2369915 | — | IC50 | = | 0.408 | nM | 9.39 |
| CHEMBL2369893 | — | IC50 | = | 5.39 | nM | 8.27 |
| CHEMBL2369899 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2369897 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2369906 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL2304022 | — | IC50 | = | 1905.0 | nM | 5.72 |
| CHEMBL2369892 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL2369905 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2369898 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2369904 | — | IC50 | > | 5000.0 | nM | - |