Assay Detail
Functional
CHEMBL654546
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Antiviral activity was measured as IC50 by calculating amount of virus present in CEM cells by beta-galactosidase assay.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.92 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 5.92 |
| CHEMBL58057 | — | — | 1 | 5.44 |
| CHEMBL59548 | — | — | 1 | 4.21 |
| CHEMBL36586 | — | — | 1 | 4.10 |
| CHEMBL39823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL58057 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL59548 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL36586 | — | IC50 | = | 79800.0 | nM | 4.10 |
| CHEMBL39823 | — | IC50 | > | 100000.0 | nM | - |