Assay Detail
Functional
CHEMBL654553
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Concentration of compound required to inhibit 50% of viral replication of human immunodeficiency virus in CEM-F cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.00 |
| CHEMBL444314 | — | — | 1 | 6.42 |
| CHEMBL1794993 | — | — | 1 | 6.25 |
| CHEMBL591804 | NAVURIDINE | 2.0 | 1 | 5.56 |
| CHEMBL1794992 | — | — | 1 | 5.30 |
| CHEMBL1791024 | — | — | 1 | 5.06 |
| CHEMBL1794990 | — | — | 1 | 4.92 |
| CHEMBL1791030 | — | — | 1 | 4.90 |
| CHEMBL1794994 | — | — | 1 | 4.57 |
| CHEMBL1794991 | — | — | 1 | 4.55 |
| CHEMBL443742 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL444314 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1794993 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL591804 | NAVURIDINE | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL1794992 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL1791024 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL1794990 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1791030 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1794994 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL1794991 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL443742 | — | IC50 | = | 48000.0 | nM | 4.32 |